Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW- v 3 interactions

Epinephrine Acts Via Erythroid Signaling Pathways to Activate Sickle Cell Adhesion to Endothelium Via LW-avb3 Interactions

RED CELLS Epinephrine acts through erythroid signaling pathways to activate sickle cell adhesion to endothelium via LW- v 3 interactions

The possible role of physiologic stress hormones in enhancing adhesion of sickle erythrocytes (SS RBCs) to endothelial cells (ECs) in sickle cell disease (SCD) has not been previously explored. We have now found that up-regulation of intracellular cyclic adenosine monophosphate (cAMP)–dependent protein kinase A (PKA) by epinephrine significantly increased sickle but not normal erythrocyte adhes...

Adhesion to Endothelium Via LW- Epinephrine Acts Via Erythroid Signaling Pathways to Activate Sickle Cell

(1930 articles) Signal Transduction • (1174 articles) Red Cells • (2497 articles) Hemostasis, Thrombosis, and Vascular Biology • (790 articles) Cell Adhesion and Motility • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its ent...

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

Sickle red cell (SS RBC) adhesion is believed to contribute to the process of vaso-occlusion in sickle cell disease (SCD). We previously found that the LW RBC adhesion receptor can be activated by epinephrine to mediate SS RBC adhesion to endothelial alphavbeta3 integrin. To determine the contribution of LW activation to vaso-occlusive events in vivo, we investigated whether in vitro treatment ...

Sickle red cells induce adhesion of lymphocytes and monocytes to endothelium.

Infusion of epinephrine-activated human sickle erythrocytes (SS RBCs) into nude mice promotes both SS RBC and murine leukocyte adhesion to vascular endothelium in vivo. We hypothesized that interaction of epinephrine-stimulated SS RBCs with leukocytes leads to activation of leukocytes, which then adhere to endothelial cells (ECs). In exploring the underlying molecular mechanisms, we have found ...